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2 edition of Physico-chemical considerations in the microencapsulation of a drug susceptible to hydrolysis found in the catalog.

Physico-chemical considerations in the microencapsulation of a drug susceptible to hydrolysis

Michael G. (Michael Gilles) Vachon

Physico-chemical considerations in the microencapsulation of a drug susceptible to hydrolysis

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  • 8 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 165 leaves
Number of Pages165
ID Numbers
Open LibraryOL20986792M

  Microencapsulation is a process by which very tiny droplets or particles of liquid or solid material are surrounded or coated with a continuous film of polymeric material. The product obtained by this process is called as micro particles, microcapsules.   Intro to Drug & Dosage Form Design 1. physicochemical characteristics of a drug substance and drug product to in- vivo bioavailability • BCS categorized drugs according to two key physico- chemical parameters: – Solubility – Permeability • These two factors were selected because most orally administered drugs are absorbed via a. Bendamustine is an alkylating agent that may hydrolyze under environmental conditions(2). Bendamustine does not contain chromophores that absorb at wavelengths > nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). (C) Encapsys, LLC. Find out how Encapsys Microencapsulation can give you the edge in your markets. Give us a call today to put our scientists and technology to work for you!

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Physico-chemical considerations in the microencapsulation of a drug susceptible to hydrolysis by Michael G. (Michael Gilles) Vachon Download PDF EPUB FB2

Microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage.

Microencapsulation drug delivery system - an overview Keshari Roshan*, Rathore K.S, Bharkatiya Meenakshi, Mishra Amul Bhupal Nobel’s Institute of Pharmaceutical Sciences, Udaipur, Rajasthan, India. *[email protected] ABSTRACT Microencapsulation is a process in which a very tiny droplet of particle such as solid, liquid or even gas can be.

Microencapsulation is a process by which solids, liquids or even gases may be enclosed in microscopic particles formation of thin coatings of wall material around the substances. The purpose of this review is to present the state of the art regarding the physico-chemical characterization of these drug carriers, in terms of the particle size distribution, the morphology.

Coacervation of various PLAs (poly(d,1,-lactic acid)) and PLGAs (poly(d,1-lactic-co-glycolic acid)) was studied for microencapsulation of BSA powder and aqueous BSA solution, focusing on the interfacial properties between coacervate, continuous liquid and solid or aqueous BSA and on selected process by: Physico-chemical factors affecting drug absorption.

We classify physico-chemical characteristics of a drug molecule or drug particle into those that are solely related to chemical structures, and those that are related to the physical shape (e.g., crystalline forms).Cited by: 9.

sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. Microencapsulation is a process where by small discrete solid particles or small liquid droplets are surrounded and enclosed by an intact shell. Microencapsulation is used to modify and delayed drug release form pharmaceutical dosage Size: KB.

The polymeric microcapsules could be produced by different microencapsulation methods and the drug microencapsulation technology could provide the quality preservation for drug stabilization. The release of entrapped drug is controlled and prolonged for specific usages.

MICROPARTICLES OFFER VARIOUS SIGNIFICANT ADVANTAGES AS DRUG DELIVERY SYSTEMS, INCLUDING: (i) an effective protection of the encapsulated active agent against (e.g.

enzymatic) degradation, (ii) the. LITERATURE REVIEW After thorough survey Physico-chemical considerations in the microencapsulation of a drug susceptible to hydrolysis book literature there is no article related to the novel microencapsulation of losartan potassium in a controlled release pharmaceutical dosage form that has been reported in literature.

The microencapsulation of drugs into solid non-biodegradable polymericFile Size: KB. Reactions indicate hydroly sis (I) and tendency for metal-hydroxide dissolution by macromolecules (2).

(slow hydrolysis) Physico-chemical considerations of titanium as a biomaterial 12 group, or its density, is large, the macromolecule--functional-group interactions may overrule macromolecule-`clean'-surface by: Also the term “biocompatibility” needs to be considered.

“Biocompatibility” has been used as a term within the last 40 years to describe the performance of a material after “biocompatibility” definitions are debated, and may hold different meanings depending on the type of applications and strategy.In the field of microspheres, the “biocompatibility Cited by:   REASONS FOR MICROENCAPSULATION To make the formulation sustained or controlled release.

To mask the taste & odour of bitter drugs A mean of separating incompatible materials To protect the drug from environmental conditions (light, moisture & oxidation) For converting liquid into free flowing powders To prevent the gastric irritation of certain drugs Water solubility.

drugs in a free flowing powder. The drugs, which are sensitive to oxygen, moisture or light, can be stabilized by microencapsulation. Incompatibility among the drugs can be prevented by microencapsulation.

Vaporization of many volatile drugs e.g. methyl salicylate and peppermint oil can be prevented by Size: KB. AbA is one of many poorly water-soluble drug molecules that represent 33% of the drugs in the US Pharmacopeia and 90% of the new chemical entities (Rodriguez-Aller et al., ), hence many reviews have been published on the formulation of poorly water-soluble drugs (Singh et al.,Kawabata et al.,Fahr and Liu,Williams et al Author: Hayley B.

Schultz, Tahlia R. Meola, Nicky Thomas, Clive A. Prestidge. Hydrolysis of silica sources: APS and DTSACl in microencapsulation processes presents the example of the size distribution of emulsion drops obtained using the ratio between chloroform and DTSACl equal to The average size of emulsion droplets was.

To protect drugs from environmental hazards such as humidity, light, oxygen or heat. e g. vitamin A and K have been shown to be protected from moisture and oxygen through microencapsulation.

The separations of incompatible substances, eg. pharmaceutical eutectics. Microencapsulation Technology and Applications. physico-chemical (coacervation, liposomes and ionic gelation) and chemical encapsulation techniques (interfacial polymerization and molecular.

This study was carried out to investigate the addition of water-soluble isoflavone into milk by means of microencapsulation technique. The yield of microencapsulation, sensory attributes, and capsule stability of water-soluble isoflavone microcapsules in milk were measured.

Coating materials used was polyglycerol monostearate (PGMS), and core material was water-soluble by:   contents: introduction reasons for microencapsulation fundamental considerations core material coating material release mechanisms methods of preparation applications of microencapsulation physicochemical evaluation advantages conclusion 3.

Manufacturing microcapsules Physico -chemical methods Coacervation - This method of encapsulation takes advantage of the reaction of aqueous solutions of cationic and anionic polymers such as gelatin and gum arabic. The polymers form a concentrated phase called the complex coacervate.

Solving Drug Delivery Problems with Liposomal Carriers Theresa M. Allen Chap DOI: /bkch Publication Date (Print): Microparticulate drug delivery systems are an interesting and promising option when developing an oral controlled release system.

The objective of this paper is to take a closer look at microparticles as drug delivery devices for increasing efficiency of drug delivery, improving the release profile and drug targeting. In order to appreciate the.

Anaerobic digestion of waste activated sludge (WAS) is most commonly used at wastewater treatment facilities to stabilize the sludge. However, poor biodegradation efficiency of sludge and longer retention times (20–30 days) are the major limitations of anaerobic digestion method, which can be overcome by disintegrate the sludge and make intracellular material readily available to Cited by: Microencapsulation technique by emulsion solvent removal method has been applied extensively in pharmaceutical industries for various purposes such as controlled drug delivery, masking the taste and odor of drugs, protecting drugs from degradation, and protecting body from the toxic effects of the by: DRUG DEGRADATION PATHWAYS CHEMICAL DECOMPOSITION.

HYDROLYSIS Hydrolysis may be due to following reasons: Ester or amide groups react with one molecule of water and undergoes hydrolysis. Ester groups break faster than amide. Hydrolysis reaction between ionic species proceeds faster than neutral molecules. It is catalyzed by H+ and OH- ions.5/5(5).

Microencapsulation and Related Drug Processes Patrick B. Deasy School of Pharmacy University of Dublin Dublin, Ireland .1 Some Historical and Other Considerations 1 Reasons for Microencapsulation 3 Pharmacological and Physicochemical Considerations 8 General References 13 References 14 Microencapsulation of Drugs by Simple.

PPT MICROENCAPSULATION 1. MICROENCAPSULATION By SANA TABASSUM () Under the guidance of S VIJAYA VANI, Associate Professor, Department of Pharmaceutics. A Presentation On CMR COLLEGE OF PHARMACY 2.

Microencapsulation: Methods and Industrial Applications, Second Edition (Drugs and the Pharmaceutical Sciences) 2nd Edition by Simon Benita (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

Format: Hardcover. The yield of microencapsulation, sensory attributes, and capsule stability of water-soluble isoflavone microcapsules in milk were measured. Coating materials used was polyglycerol monostearate (PGMS), and core material was water-soluble by: Microencapsulation.

Genetic Modification  microencapsulation  advantages and disadvantages. Powered by Create your own unique website with customizable templates. Get Started. Purpose: The major limitation in the widespread use of liposome drug delivery system is its instability.

Lyophilization is a promising approach to ensure the long-term stability of liposomes. The aim of this study was to prepare sirolimus-loaded liposomes, study their stability and investigate the effect of lyophilization either in the presence or in the absence of lyoprotectant on liposome.

Ultimate success of microencapsulation of expensive biotech drugs requires minimal drug losses during encapsulation. In a single batch process with SM microspheres, the encapsulation efficiency (EE), was low (~ –13%) by the passive by: Chemical Based Microencapsulation Technologies: Coacervation Interfacial Polymerisation In-situ Polymerisation Liposomes Inclusion Complexation: Coacervation.

Sometimes called phase separation this technology is considered as the oldest true encapsulation technology first developed by the National Cash Register Company for carbonless copy-paper.

Release kinetics. Drug release from PLGAs can have multiple phases, which typically include (a) an initial burst phase lasting over one to several days or even a week, (b) a lag (or induction) phase where low levels of polymer erode and sometimes little or no drug release is observed, and (c) an active erosion phase, where polymer mass is continuously lost from the polymer and drug Cited by: Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation.

The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: Edition on the vast information 1/5(1). MICROENCAPSULATION OF ACID DYES IN LIPOSOMIC STRUCTURES OF LECITHIN AND SURFACTANTS GOMES, J.I.N.R., BAPTISTA, A.

Departamento de Engenharia Têxtil, Universidade do Minho, Guimarães Portugal ABSTRACT The non-uniformity which occurs in the dyeing of polyamide, caused by the irregularities in the physico-chemical properties of the fibre, is.

Microencapsulation: Methods and Industrial Applications, Second Edition (Drugs and the Pharmaceutical Sciences Book ) - Kindle edition by Benita, Simon. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Microencapsulation: Methods and Industrial Applications, Second Edition (Drugs and Manufacturer: CRC Press.

Choline bitartrate (CBT) is a water soluble essential nutrient belongs to vitamin-B family. It is moisture sensitive in nature and marketed formulation has stability related problems during storage which curtails its effectiveness. Waxes such as hydrogenated soya bean oil (HSO) reported to be an excellent coating carrier to reduce moisture sensitivity or hygroscopic nature of drug by: 5.

Rifampicin undergoes hydrolysis of the azomethine double bonds (see Scheme 23), which involves reversible hydrolysis followed by multiple secondary degradation pathways with complex pH dependencies (Fig.

78) The effect of pH on the stability of solid drug substances is generally more complex than that on the stability of drugs in solution. The stability of drug in environment to which it is exposed, is another physico-chemical factor to be considered in design at sustained/ controlled release systems, drugs that are unstable in stomach can be placed in slowly soluble forms or have their release delayed until they reach the small intestine.Abstract.

Microencapsulation is but one of many methods of obtaining controlled release of drugs and chemicals. However, when microencapsulation processes are being considered for a particular use, it is difficult to gain enough perspective on them to decide which ones to study in : Robert E.

Sparks.This book provides a comprehensive look at the important advances made in the design and production of microcapsules, microspheres, and nanoparticles. It discusses the diverse aspects and skills that must be mastered to be able to prepare and test products that will work correctly and be clinically acceptable for human or animal use.